The university was formally established in 2005 as a result of the positive feedback from the postgraduate programs in various medical fields that had been offered by the National Guard Health Affairs (NGHA) since the mid-1980s. The advanced medical facilities at the King Abdulaziz Medical Cities in Riyadh, Jeddah and Al-Ahsa proved to be critical foundations for the successful inception of the university.
KSAU-HS’s main campus is in Riyadh with two additional campuses in Jeddah and Al-Ahsa. The main campus in Riyadh hosts seven colleges: College of Medicine, College of Dentistry, College of Pharmacy, College of Public Health and Health Informatics, College of Applied Medial Sciences, College of Nursing and the College of Science & Health Professions. Jeddah Campus hosts College of Medicine, College of Nursing, College of Applied Medical Sciences and College of Sciences and Health Professions. Finally, Al-Ahsa Campus hosts College of Applied Medical Sciences, College of Nursing, and College of Sciences and Health Professions.
The umbrella of NGHA has given the KSAU-HS students access to King Abdulaziz Medical Cities in Riyadh, Jeddah and Al-Ahsa, which are considered to be the most advanced medical complexes in the region. Furthermore, it has enabled KSAU-HS to enhance its curricula and academic programs with clinical applications and training under the supervision of highly competent health professionals.